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Research on tissues and body structures and biomaterials

Porous Composite Materiáls with Polyamide Reinforcement and Siloxane Matrix with Nano-Hydroxyapatite as Biomaterials

Project description:

Mechanical and biological properties optimization of composites using modification of matrix by calcium phosphate nano and micro particles. Addition of CaP particles into the composites matrix has a possitive influence on their biocompatibility.

An example of in vitro bioactivity testing (soaking of composites in simulated body fluid; SBF) - apatite formation on composite surfaces in SBF is useful for predicting the in vivo bone bioactivity.

Different volume fraction of calcium phosphates particles in composite matrix has a strong influence on bone cells rection (MG-63 cells, pictures: Institute of Physiology, ASCR).

The project aims at designing and developing composite material with optimum size pores and suitable mechanical properties for potential bone tissue engineering. The composite consists of polyamide fabrics embedded in siloxane matrix with hydroxyapatite micro- or nanocrystals uniformously dispersed in the matrix. In vitro and in vivo tests with histological documentation are carried out on prepared composites and implants. Application of the composite to be developed on selected bone replacements.

Resesrchers:

Cooperation:

Literature:

• Balík K, Suchý T, Sucharda Z, Rýglová Š, Denk F. Design for a filler of an intervertebral cage for spine treatment on the basis of fibers and particulate composites. Ceramics-Silikáty 2009;52(4):310-14.
• Balík K, Suchý T, Sucharda Z, Černý M, Bačáková L, Sochor M, Šlouf M. Effect of nano/micro particles of calcium phosphates on the mechanical properties of composites based on polysiloxane matrix reinforced by polyamide. Ceramics-Silikáty 2008;52(4):260-67.
• Suchý T, Balík K, Černý M, Sochor M, Hulejová H, Pešáková V, Fenclová T. A composite based on glass fibers and siloxane matrix as bone replacement. Ceramics-Silikáty 2008;52(1):29-36.
• Suchý T, Balík K, Sucharda Z, Černý M, Sochor M. Mechanical behavior of polymer-matrix biocomposites modified by nano/micro additives. Engineering of Biomaterials 2008;11(77-80):8-10.
• Suchý T, Balík K, Sucharda Z, Černý M, Sochor M. Influence of nanoparticles additives on mechanical properties of fabric reinforced composites. Engineering of Biomaterials 2007;10(69-72):1-2.