Cardiovascular system and artificial replacements
Research on tissues and body structures and biomaterials
Medical and health applications
Stent-artery wall interaction
Project description:
- Intracoronary stenting has become standard revascularization interventional technique worldwide. Alone in the USA and in Europe more than 2 Millions stenting interventions are performed annually. A revascularization is achieved by intraluminal expansion of a stent.
- There are two basic stent designs; so-called balloon-expandable, which expand at the target location due to the pressurized balloon inducing plastic deformation in stent’s material, and so-called self-expandable (manufactured form shape memory alloys like Nitinol).
- In order to obtain detailed description of a stent and artery kinematics (stent-artery interaction), ex vivo experimental stent dilation are carried out in our laboratory.
Left - Principle of percutaneous coronary intervention with a stent deployment.
Center - Experimental setup.
Right - Results of contour analysis.
Representative example of surface strain field of coronary artery wall with ex vivo experimentally implanted stent.
Publications
L. Horny, H. Chlup, R. Zitny, T. Vonavkova, J. Vesely, P. Lanzer (2012) Ex vivo coronary stent implantation evaluated with digital image correlation. Experimental Mechanics, in press. DOI: 10.1007/s11340-012-9620-6
L. Horny, H. Chlup, J. Vesely, E. Gultova, J. Kronek, R. Zitny, T. Vonavkova, T. Adamek, P. Lanzer, D. Hromadka (2011) In vitro Coronary Stent Implantation: Vessel Wall-Stent Interaction. IFMBE Proceedings 37:795-798. DOI: 10.1007/978-3-642-23508-5_207
doc. Ing. Lukáš Horný Ph.D. ; Hynek Chlup
Resesrchers:
Department of Forensic Medicine of the Third Faculty of Medicine Charles University in Prague and University Hospital Na Kralovskych Vinohradech
Department of Cardiology of the Second Medical School Charles University in Prague nad University Hospital Motol